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KMID : 1130320090520121348
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Korean Journal of Pediatrics
2009 Volume.52 No. 12 p.1348 ~ p.1357
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Changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis
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Jo Dae-Sun
Lee Dae-Yeol
Hwang Pyoung-Han
Kim Min-Sun
Yi Ho-Keun
Kim Sun-Young
Han Ji-Hye
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Abstract
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Purpose: The aims of this study were to identify the clinical characteristics and determine the changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis.
Methods: Serological examinations of 15 pediatric patients diagnosed with infectious mononucleosis were performed prospectively. Peripheral blood from the patients was used to compare the composition of T cell subsets, cytokines, Epstein?Barr virus (EBV) DNA, and the expression of apoptosis-related genes with those in 10 healthy children.
Results: Mean age of the patient group was 5.7±3.4 (range, 3?9) years, and the male-to-female ratio was 1.5:1. Fever, sore throat, pharyngitis/tonsillitis, and cervical lymph node enlargement were the most common symptoms and signs. The proportions of CD3+ T cells, CD8+ suppressor cells, and CD56+ natural killer (NK) cells were higher in the patient group than in the control group (P<0.01). The IL-2, IL-6, and interferon (IFN)-γ levels were higher in the early symptomatic period (P<0.01). Mean amount of EBV DNA in the patients was 102.38 copies/μg, and the amount was the highest at the beginning of the symptomatic period and normalized during the convalescent phase. Bcl-2 expression increased during the initial phase, while Bax expression increased during the convalescent phase. Further, FasL expression increased 1 week after symptom presentation and decreased during the convalescent phase. There was no significant change in Fas expression.
Conclusion: We analyzed the clinical characteristics and changes in the expression ofcytokines and apoptosis-related genes in the patients with infectious mononucleosis.
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KEYWORD
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Infectious Mononucleosis, Cytokines, Apoptosis, Children, Gene
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